tailieunhanh - Báo cáo y học: "Aspergillus antigen induces robust Th2 cytokine production, inflammation, airway hyperreactivity and fibrosis in the absence of MCP-1 or CCR2"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:"Aspergillus antigen induces robust Th2 cytokine production, inflammation, airway hyperreactivity and fibrosis in the absence of MCP-1 or CCR2. | Respiratory Research BioMed Central Research Open Access Aspergillus antigen induces robust Th2 cytokine production inflammation airway hyperreactivity and fibrosis in the absence of MCP-1 or CCR2 Laura L Koth1 2 Madeleine W Rodriguez1 Xin Liu Bernstein1 Salina Chan1 Xiaozhu Huang1 Israel F Charo4 Barrett J Rollins5 and David J Erie 1 2 3 Address 1Lung Biology Center Department of Medicine University of California San Francisco California USA 2Cardiovascular Research Institute University of California San Francisco California USA 3Program in Immunology University of California San Francisco California USA 4Gladstone Institute of Cardiovascular Disease University of California San Francisco California USA and 5Department of Adult Oncology Dana-Farber Cancer Institute Harvard Medical School Boston Massachusetts USA Email Laura L Koth - lkoth@ Madeleine W Rodriguez - mwrod@ Xin Liu Bernstein - xinliub@ Salina Chan - salinac@ Xiaozhu Huang - benny@ Israel F Charo - icharo@ Barrett J Rollins - Barrett_Rollins@ David J Erle - erle@ Corresponding author Published 15 September 2004 Received 29 May 2004 Accepted 15 September 2004 Respiratory Research 2004 5 12 doi 1465-9921-5-12 This article is available from http content 5 1 12 2004 Koth et al licensee BioMed Central Ltd. This is an open-access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Asthma is characterized by type 2 T-helper cell Th2 inflammation goblet cell hyperplasia airway hyperreactivity and airway fibrosis. Monocyte chemoattractant protein-1 MCP-l or CCL2 and its receptor CCR2 have been shown to play important roles in the development of Th2 inflammation.