tailieunhanh - Báo cáo y học: " Aplastic anemia associated with interferon alpha 2a in a patient with chronic hepatitis C virus infection: a case report"

Tham khảo luận văn - đề án 'báo cáo y học: " aplastic anemia associated with interferon alpha 2a in a patient with chronic hepatitis c virus infection: a case report"', luận văn - báo cáo phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả | loannou et al. Journal of Medical Case Reports 2010 4 268 http content 4 1 268 jAc JOURNALOF medical ÌỤr case REPORTS CASE REPORT Open Access Aplastic anemia associated with interferon alpha 2a in a patient with chronic hepatitis C virus infection a case report Savvas loannou Gregorios Hatzis Ioanna Vlahadami Michael Voulgarelis Abstract Introduction Hepatitis-associated aplastic anemia is a common syndrome in patients with bone marrow failure. However hepatitis-associated aplastic anemia is an immune-mediated disease that does not appear to be caused by any of the known hepatitis viruses including hepatitis C virus. In addition to the best of our knowledge there are no reported cases of patients with chronic hepatitis C virus infection developing aplastic anemia associated with pegylated interferon alpha 2a treatment. Case presentation We report the case of a 46-year-old Greek man who developed severe aplastic anemia during treatment with pegylated interferon alpha 2a for chronic hepatitis C virus infection. He presented with generalized purpura and bruising as well as pallor of the skin and mucous membranes. His blood tests showed pancytopenia. He underwent allogeneic bone marrow transplantation after completing two courses of immunosuppressive therapy with antithymocyte globulin and cyclosporin A. Conclusions The combination of a specific environmental precipitant represented by the hepatitis C virus infection an altered metabolic detoxification pathway due to treatment with pegylated interferon alpha 2a and a facilitating genetic background such as polymorphism in metabolic detoxification pathways and specific human leukocyte antigen genes possibly conspired synergistically in the development of aplastic anemia in this patient. Our case clearly shows that the causative role of pegylated interferon alpha 2a in the development of aplastic anemia must not be ignored. Introduction Hepatitis C virus HCV infection is a major public health

TÀI LIỆU LIÊN QUAN
TÀI LIỆU MỚI ĐĂNG
crossorigin="anonymous">
Đã phát hiện trình chặn quảng cáo AdBlock
Trang web này phụ thuộc vào doanh thu từ số lần hiển thị quảng cáo để tồn tại. Vui lòng tắt trình chặn quảng cáo của bạn hoặc tạm dừng tính năng chặn quảng cáo cho trang web này.