tailieunhanh - Báo cáo y học: "Bronchospasm and its biophysical basis in airway smooth muscle"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:Bronchospasm and its biophysical basis in airway smooth muscle. | Respiratory Research BioMed Central Review Open Access Bronchospasm and its biophysical basis in airway smooth muscle Jeffrey J Fredberg Address Harvard School of Public Health 665 Huntington Avenue Boston MA 02115 USA Email JeffreyJ Fredberg - jfredber@ Corresponding author Published 26 February 2004 Received 03 September 2003 Accepted 26 February 2004 Respiratory Research 2004 5 2 This article is available from http content 5 1 2 2004 Fredberg licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract Airways hyperresponsiveness is a cardinal feature of asthma but remains unexplained. In asthma the airway smooth muscle cell is the key end-effector of bronchospasm and acute airway narrowing but in just the past five years our understanding of the relationship of responsiveness to muscle biophysics has dramatically changed. It has become well established for example that muscle length is equilibrated dynamically rather than statically and that non-classical features of muscle biophysics come to the forefront including unanticipated interactions between the muscle and its time-varying load as well as the ability of the muscle cell to adapt rapidly to changes in its dynamic microenvironment. These newly discovered phenomena have been described empirically but a mechanistic basis to explain them is only beginning to emerge. Introduction It is self-evident that acute narrowing of the asthmatic airway and shortening of the airway smooth muscle are inextricably linked. Nonetheless it was many years ago that research on the asthmatic airway and research on the biophysics of airway smooth muscle ASM had a parting of the ways 1 . The study of smooth muscle biophysics took on a life of its own and pursued a deeply reductionist agenda one that became focused to