tailieunhanh - Báo cáo y học: " Association studies for asthma and atopic diseases: a comprehensive review of the literature"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: Association studies for asthma and atopic diseases: a comprehensive review of the literature. | Respiratory Research BioMed Central Review Association studies for asthma and atopic diseases a comprehensive review of the literature Sabine Hoffjan1 Dan Nicolae2 and Carole Ober 1 Open Access Address departments of Human Genetics The University of Chicago Chicago IL 60637 USA and departments of Statistics The University of Chicago Chicago IL 60637 USA Email Sabine Hoffjan - reimsbach@ Dan Nicolae - nicolae@ Carole Ober - c-ober@ Corresponding author Published 04 December 2003 Received 07 August 2003 Accepted 04 December 2003 Respiratory Research 2003 4 14 r This article is available from http content 4 1 14 2003 Hoffjan et al licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract Hundreds of genetic association studies on asthma-related phenotypes have been conducted in different populations. To date variants in 64 genes have been reported to be associated with asthma or related traits in at least one study. Of these 33 associations were replicated in a second study 9 associations were not replicated either in a second study or a second sample in the same study and 22 associations were reported in just a single published study. These results suggest the potential for a great amount of heterogeneity underlying asthma. However many of these studies are methodologically limited and their interpretation hampered by small sample sizes. Review Two general approaches have been widely used to study the genetics of asthma genome-wide linkage studies followed by positional cloning and candidate gene association studies. The results of linkage studies for asthma have been described in detail elsewhere 1-3 this review focuses on the published candidate gene association studies for asthma. Candidate gene approach basic .