tailieunhanh - Báo cáo y học: "The effects of dopamine and epinephrine on hemodynamics and oxygen metabolism in hypoxic anesthetized piglets"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: The effects of dopamine and epinephrine on hemodynamics and oxygen metabolism in hypoxic anesthetized piglets. | Available online http content 5 3 158 Primary research The effects of dopamine and epinephrine on hemodynamics and oxygen metabolism in hypoxic anesthetized piglets Po-Yin Cheung and Keith J Barrington1 University of Alberta Edmonton Alberta Canada McGill University Montreal Quebec Canada Correspondence KJ Barrington MBChB FRCP C MRCP UK Room Royal Victoria Hospital 687 Pine Ave W Montreal Quebec Canada H3A 1A1. Tel 514 842 1231 ext 4876 fax 514 843 1741 e-mail kbarri@ Received 10 November 2000 Revisions requested 14 December 2000 Revisions received 28 February 2001 Accepted 12 April 2001 Published 26 April 2001 Critical Care 2001 5 158-166 2001 Cheung and Barrington et al licensee BioMed Central Ltd Print ISSN 1364-8535 Online ISSN 1466-609X Abstract Background The most appropriate inotropic agent for use in the newborn is uncertain. Dopamine and epinephrine are commonly used but have unknown effects during hypoxia and pulmonary hypertension the effects on the splanchnic circulation in particular are unclear. Methods The effects on the systemic pulmonary hepatic and mesenteric circulations of infusions of dopamine and epinephrine adrenaline were compared in 17 newborn piglets. Three groups control n 5 dopamine n 6 and epinephrine n 6 of fentanyl anesthetized newborn piglets were instrumented to measure cardiac index CI hepatic arterial and portal venous blood flow mean systemic arterial pressure SAP mean pulmonary arterial pressure PAP and arterial portal and mixed venous oxygen saturations. Systemic pulmonary and mesenteric vascular resistance indices systemic vascular resistance index SVRI pulmonary vascular resistance index PVRI mesenteric vascular resistance index MVRI and systemic and splanchnic oxygen extraction and consumption were calculated. Alveolar hypoxia was induced with arterial oxygen saturation being maintained at 55-65 . After 1 h of stabilization during hypoxia each animal received either dopamine or epinephrine

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