tailieunhanh - Báo cáo y học: "Effects of an angiotensin II antagonist on organ perfusion during the post-resuscitation phase in pigs"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Effects of an angiotensin II antagonist on organ perfusion during the post-resuscitation phase in pigs. | Available online http content 2 2 49 Research Effects of an angiotensin II antagonist on organ perfusion during the post-resuscitation phase in pigs Hans-Ulrich Strohmenger1 Karl H Lindner1 Wolfgang Wienen2 and Peter Radermacher1 1 Department of Anesthesiology and Critical Care Medicine University of Ulm Ulm Germany. 2Department of Pharma Research Dr Karl Thomae GmbH Biberach Germany. Received 4 August 1997 Revisions requested 20 October 1997 Revisions received 24 February 1998 Accepted 1 March 1998 Published 22 May 1998 1998 Current Science Ltd Print ISSN 1364-8535 Online ISSN 1466-609X Crit Care 1998 2 49 Abstract Background The aim of this study was to compare pre-arrest and post-resuscitation organ perfusion values and to investigate whether during the post-resuscitation phase administration of the angiotensin II antagonist telmisartan TELM 10 min after restoration of spontaneous circulation ROSC could improve organ flow in comparison to placebo. Results Five minutes after ROSC in the TELM group blood flow in the cortex and myocardium increased to 583 P and 137 not significant respectively whereas blood flow of the colon stomach and pancreas decreased to 50 P 28 P and 19 P of pre-arrest values respectively. At 90 min after ROSC pre-arrest perfusion values both in non-splanchnic and splanchnic organs were achieved. At no point in time were there significant differences between the two groups with respect to organ blood flow or speed of recovery of organ perfusion. Conclusions During the post-resuscitation phase organ blood flow is characterized by the coincidence of increased cerebral and myocardial blood flow and decreased intestinal blood flow. Administration of TELM 10 min after ROSC did not improve the recovery of organ perfusion. Keywords angiotensin II antagonist cardiopulmonary resuscitation organ perfusion post-resuscitation phase telmisartan Introduction In an effort to improve the dismal outcome of cardiac arrest a .