tailieunhanh - Báo cáo y học: "Close relationship of tissue plasminogen activator–plasminogen activator inhibitor-1 complex with multiple organ dysfunction syndrome investigated by means of the artificial pancreas"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Close relationship of tissue plasminogen activator–plasminogen activator inhibitor-1 complex with multiple organ dysfunction syndrome investigated by means of the artificial pancreas. | Available online http content 5 2 088 Primary research Close relationship of tissue plasminogen activator-plasminogen activator inhibitor-1 complex with multiple organ dysfunction syndrome investigated by means of the artificial pancreas Masami Hoshino Yoshikura Haraguchi Hiroyuki Hirasawa Motohiro Sakai Hiroshi Saegusa Kazushiro Hayashi Naoki Horita and Hiroyuki Ohsawa Department of Intensive and Critical Care Medicine Tokyo Police Hospital Chiyoda-ku Tokyo Japan National Hospital Tokyo Disaster Medical Center Tachikawa-shi Tokyo Japan Department of Emergency and Critical Care Medicine Chiba University School of Medicine Chuo-ku Chiba-shi Chiba Japan Correspondence Masami Hoshino Department of Intensive and Critical Care Medicine Tokyo Police Hospital Fujimi 2-10-41 Chiyoda-ku Tokyo 102 Japan. Tel 81 3 3263 1371 fax 81 3 3239 7856 e-mail noel2000@ Received 1 December 1998 Revisions requested 17 April 2000 Revisions received 1 June 2000 Accepted 18 November 2000 Published 26 February 2001 Critical Care 2001 5 88-99 2001 Hoshino et al licensee BioMed Central Ltd Print ISSN 1364-8535 Online ISSN 1466-609X Abstract Background Glucose tolerance GT has not been taken into consideration in investigations concerning relationships between coagulopathy and multiple organ dysfunction syndrome MODS and endothelial cell activation endothelial cell injury ECA ECI in septic patients although coagulopathy is known to be influenced by blood glucose level. We investigated those relationships under strict blood glucose control and evaluation of GT with the glucose clamp method by means of the artificial pancreas in nine septic patients with glucose intolerance. The relationships between GT and blood stress related hormone levels SRH were also investigated. Methods The amount of metabolized glucose M value as the parameter of GT was measured by the euglycemic hyperinsulinemic glucose clamp method in which the blood glucose level was clamped at 80 mg dl .