tailieunhanh - Báo cáo y học: "Measuring the lung function in the mouse: the challenge of size"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "Measuring the lung function in the mouse: the challenge of size. | Respiratory Research BioMed Central Review Open Access Measuring the lung function in the mouse the challenge of size Charles G Irvin and Jason HT Bates Address Vermont Lung Center Department of Medicine College of Medicine University of Vermont Room 226 HSRF 149 Beaumont Avenue Burlington VT 05405 USA Email Charles G Irvin - Jason HT Bates - jhtbates@ Corresponding author Published 15 May 2003 Received 30 August 2002 Accepted 14 January 2003 Respir Res 2003 4 4 This article is available from http content 4 l 4 2003 Irvin et al. licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract Measurement of the effects of drugs mediators and infectious agents on various models of lung disease as well as assessment of lung function in the intact mouse has the potential for significantly advancing our knowledge of lung disease. However the small size of the mouse presents significant challenges for the assessment of lung function. Because of compromises made between precision and noninvasiveness data obtained may have an uncertain bearing on the mechanical response of the lung. Nevertheless considerable recent progress has been made in developing valid and useful measures of mouse lung function. These advances resulting in our current ability to measure sophisticated indices of lung function in laboratory animals are likely to lead to important insights into the mechanisms of lung disease. Introduction Much of our current understanding of the normal functioning of the lung and mechanisms of lung disease comes from studies utilizing animals. As one clear example animal systems of a wide variety of species including humans provided the essential mechanistic proof of a link between inflammation and airways hyperresponsiveness that set the stage