tailieunhanh - Báo cáo khoa hoc:" Lipoprotein(a) and inflammation in patients with atrial fibrillation after electrical cardioversion"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Lipoprotein(a) and inflammation in patients with atrial fibrillation after electrical cardioversion | Naji and Sabovic Journal of Negative Results in BioMedicine 2011 10 15 http content 10 1 15 r M 1 JOURNAL OF NEGATIVE RESULTS IN BIOMEDICINE RESEARCH Open Access Lipoprotein a and inflammation in patients with atrial fibrillation after electrical cardioversion Franjo Naji1 and Miso Sabovic2 Abstract Background Recently few studies tried to confirm the association between AF and lipoprotein a Lp a however the results remained conflicted. In present study we evaluated the possible interaction between Lp a inflammatory state and echocardiographic characteristics in patients after successful electrical cardioversion EC of persistent AF. We also tried to investigate the role of Lp a as a possible prognostic factor for AF recurrence after successful EC. Results Data of 79 patients admitted due to planned EC was analyzed. After successful procedure patients were monitored for 2 years. For analytical purposes patients were divided in two groups according to AF recurrence. There was no significant difference between Lp a levels in both groups. We also didn t find any positive correlation between Lp a and CRP levels as well as between Lp a levels and left atrium diameter. For logistic and survival analysis optimal cut-off value of Lp a upper quartile was used. In logistic regression model with AF recurrence as dependent variable Lp a didn t show any statistically significant association with AF recurrence. Survival analysis showed slightly higher AF recurrence rate in group with higher Lp a levels but not to the level of statistical significance log rank test p . Conclusions We weren t able to confirm the association between Lp a levels and AF recurrence inflammation and left atrium diameter in patients after successful EC of persistent AF. Further studies are needed to elucidate the role of Lp a in this clinical setting. Keywords atrial fibrillation lipoprotein a cardioversion inflammation Introduction Atrial fibrillation AF is one of major causes .