tailieunhanh - Báo cáo y học: The predictive role of serum and bronchoalveolar lavage cytokines and adhesion molecules for acute respiratory distress syndrome development and outcome

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " The predictive role of serum and bronchoalveolar lavage cytokines and adhesion molecules for acute respiratory distress syndrome development and outcome. | Available online http content 3 1 25 Research article The predictive role of serum and bronchoalveolar lavage cytokines and adhesion molecules for acute respiratory distress syndrome development and outcome Panagiotis Agouridakis1 Despina Kyriakou2 Michael G Alexandrakis2 Athanasios Prekates4 Kostas Perisinakis5 Nikolaos Karkavitsas6 and Demosthenes Bouros3 1Intensive Care Unit General Hospital of Rethymnon Crete Greece 2Department of Hematology University Hospital of Heraklion Crete Greece 3Department of Pneumonology University Hospital of Heraklion Crete Greece intensive Care Unit Tzanion General Hospital of Pireus Crete Greece 5Department of Medical Physics University Hospital of Heraklion Crete Greece 6Department of Nuclear Medicine University Hospital of Heraklion Crete Greece Correspondence Demosthenes Bouros - bouros@ Received 18 January 2002 Respir Res 2002 3 25 Revisions requested 26 February 2002 Revisions received 16 May 2002 Accepted 6 June 2002 Published 23 October 2002 2002 Agouridakis et al licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any non-commercial purpose provided this notice is preserved along with the article s original URL. Print ISSN 1465-9921 Online ISSN 1 465-993X Abstract Background The predictive role of many cytokines and adhesion molecules has not been studied systematically in acute respiratory distress syndrome ARDS . Methods We measured prospectively tumour necrosis factor alpha TNF-a interleukin IL -1 soluble vascular adhesion molecule-1 VCAM-1 and soluble intercellular adhesion molecule-1 ICAM-1 in serum and bronchoalveolar lavage fluid BALF within 2 hours following admission in 65 patients. The patients were divided into those fulfilling the criteria for ARDS n 23 group A those who were preARDS and who developed ARDS within 24 hours n 14 group B and those on pre-ARDS but who never developed ARDS n