tailieunhanh - Báo cáo y học: " Interactions between genes and environmental factors in asthma and atopy: new developments"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" Interactions between genes and environmental factors in asthma and atopy: new developments. | Available online http content 3 1 7 Review Interactions between genes and environmental factors in asthma and atopy new developments Claudia Sengler Susanne Lau Ulrich Wahn and Renate Nickel Department of Pediatric Pneumology and Immunology Charité Humboldt University Berlin Berlin Germany Correspondence Renate Nickel Department of Pediatric Pneumology and Immunology Charité Humboldt University Augustenburger Platz 1 D-13353 Berlin Germany. Tel 49 30 4505 66131 fax 49 30 4505 66931 e-mail Received 10 April 2001 Revisions requested 7 June 2001 Revisions received 10 July 2001 Accepted 27 July 2001 Published 31 October 2001 Respir Res 2002 3 7 2002 BioMed Central Ltd Print ISSN 1465-9921 Online ISSN 1465-993X Abstract Asthma and associated phenotypes are complex traits most probably caused by an interaction of multiple disease susceptibility genes and environmental factors. Major achievements have occurred in identifying chromosomal regions and polymorphisms in candidate genes linked to or associated with asthma atopic dermatitis IgE levels and response to asthma therapy. The aims of this review are to explain the methodology of genetic studies of multifactorial diseases to summarize chromosomal regions and polymorphisms in candidate genes linked to or associated with asthma and associated traits to list genetic alterations that may alter response to asthma therapy and to outline genetic factors that may render individuals more susceptible to asthma and atopy due to environmental changes. Keywords asthma atopy environment genetics infection Introduction The prevalence of asthma allergic rhinitis and atopic dermatitis AD has dramatically increased over the past decades. These atopy-related diseases are the most common chronic disorders in childhood in Western societies. Several epidemiological studies have evaluated environmental risk factors that may explain the steady increase of allergic disease. Note in this article