tailieunhanh - Báo cáo y học: "Genotyping in the MHC locus: potential for defining predictive markers in sarcoidosis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:"Genotyping in the MHC locus: potential for defining predictive markers in sarcoidosis. | Available online http content 3 1 6 Review Genotyping in the MHC locus potential for defining predictive markers in sarcoidosis Ulrike Seitzer Johannes Gerdes and Joachim Muller-Quernheim Division of Molecular Immunology Department of Immunology and Cell Biology Research Center Borstel Borstel Germany Division of Clinical Immunopathophysiology Department of Clinical Medicine Research Center Borstel Borstel Germany Correspondence Ulrike Seitzer Division of Molecular Immunology Department of Immunology and Cell Biology Research Center Borstel Parkallee 22 23845 Borstel Germany. Tel 49 4537 188 418 fax 49 4537 188 724 e-mail useitzer@ Received 2 July 2001 Revisions requested 13 August 2001 Revisions received 24 August 2001 Accepted 3 September 2001 Published 25 October 2001 Respir Res 2002 3 6 2002 BioMed Central Ltd Print ISSN 1465-9921 Online ISSN 1465-993X Abstract In sarcoidosis host genetic factors are discussed as contributing to disease susceptibility and course. Since tumor necrosis factor TNF -a is a central mediator of granuloma formation and since elevated TNF-a levels are found during active phases of sarcoidosis genetic polymorphisms correlating with influences on TNF-a levels are of special interest. The complete sequencing of the MHC region and the increase in the number of identified gene polymorphisms in this locus associated with TNF-a production offer the opportunity of detecting new genes associated with sarcoidosis and perhaps of defining disease-associated haplotypes that bear the potential of serving as predictive markers for this disease. Keywords disease haplotypes gene polymorphisms HLA-DR tumor necrosis factor-a Introduction Sarcoidosis is a multisystemic granulomatous disease of unknown etiology in which environmental exposures are believed to interact with genetic factors in determining the pattern of sarcoidosis presentation progression and prognosis 1-3 . The consensus is that the disease results .