tailieunhanh - Báo cáo khoa hoc:" Vitamin D receptor gene polymorphisms in multiple sclerosis patients in northwest Greece"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Vitamin D receptor gene polymorphisms in multiple sclerosis patients in northwest Greece | Sioka et al. Journal of Negative Results in BioMedicine 2011 10 3 http content 10 1 3 r M 1 JOURNAL OF NEGATIVE RESULTS IN BIOMEDICINE RESEARCH Open Access Vitamin D receptor gene polymorphisms in multiple sclerosis patients in northwest Greece Chrissa Sioka1 Stylianos Papakonstantinou2 3 Sofia Markoula2 Foteini Gkartziou4 Athanasia Georgiou1 loannis Georgiou4 Sygliti-Henrietta Pelidou2 3 Athanassios P Kyritsis2 3 and Andreas Fotopoulos1 Abstract Background Polymorphisms of the vitamin D receptor VDR gene have been linked to both multiple sclerosis MS and osteoporosis. We examined the frequency of the Taq-I and Bsm-I polymorphisms of the vitamin D receptor VDR gene in 69 patients with MS and 81 age and sex-matched healthy individuals. Genotyping of Taq-I rs731236 and Bsm-I rs1544410 was performed using TaqMan SNP Genotyping Assay. All patients and controls had determination of body mass index BMI bone mineral density BMD and smoking history. Results The mean age of patients was 39 years compared to years of the controls p the BMI was kg m2 compared to kg m2 of the controls p the BMD in the lumbar spine compared to 013 of the controls p and the total hip BMD was compared to of the controls p . There were no differences of the Taq-I TT CT CC and Bsm-I genotypes GG GA AA and allelic frequencies between MS and control individuals. Multivariate analysis also failed to show any association of the Taq-I and Bsm-I polymorphisms and MS or sex BMI BMD and smoking history. Conclusions This study suggests that the Taq-I and Bsm-I polymorphisms of the VDR gene are not associated with MS risk BMI or BMD in the Greek population studied. Background Multiple sclerosis MS is a progressive demyelinating disease of the central nervous system CNS that occurs mainly in young adults frequently leading to substantial disability several years after diagnosis 1 . Vitamin D is essential

TÀI LIỆU LIÊN QUAN
crossorigin="anonymous">
Đã phát hiện trình chặn quảng cáo AdBlock
Trang web này phụ thuộc vào doanh thu từ số lần hiển thị quảng cáo để tồn tại. Vui lòng tắt trình chặn quảng cáo của bạn hoặc tạm dừng tính năng chặn quảng cáo cho trang web này.