tailieunhanh - Báo cáo toán học: " Lower striatal dopamine D2/3 receptor availability in obese compared with non-obese subjects"

Tuyển tập các báo cáo nghiên cứu khoa học ngành toán học được đăng trên tạp chí toán học quốc tế đề tài: Lower striatal dopamine D2/3 receptor availability in obese compared with non-obese subjects | de Weijer et al. EJNMMI Research 2011 1 37 http content 1 1 37 9 EJNMMI Research a SpringerOpen Journal SHORT COMMUNICATION Open Access Lower striatal dopamine D2 3 receptor availability in obese compared with non-obese subjects o LZ LZ- A J A M LZ 1 f Dlr I ri J t mn r l S-. f _ I f I-1- LZ 2 f I p. A LZ r A t mn A m S-. I r r f r 3 c r ỉ I D fs z -3 4 D ro z D I 5 Barbara A de weijer ElsmarieKe van de Giessen inerese A van Amelsvoort EriK Boot Dreg BraaK Ignace M Janssen6 Arnold van de Laar7 Eric Fliers1 Mireille J Serlie1 and Jan Booij2 Abstract Background Obesity is a result of a relative excess in energy intake over energy expenditure. These processes are controlled by genetic environmental psychological and biological factors. One of the factors involved in the regulation of food intake and satiety is dopaminergic signalling. A small number of studies have reported that striatal dopamine D2 D3 receptor D2 3R availability is lower in morbidly obese subjects. Methods To confirm the role of D2 3R in obesity we measured striatal D2 3R availability using 123I IBZM SPECT in 15 obese women and 15 non-obese controls. Results Striatal D2 3R availability was 23 p lower in obese compared with non-obese women. Conclusion This study is an independent replication of the finding that severely obese subjects have lower striatal D2 3R availability. Our findings invigorate the evidence for lower striatal D2 3R availability in obesity and confirm the role of the striatal dopaminergic reward system in obesity. Keywords obesity dopamine receptor availability 123I IBZM SPECT Background Over the last decades the average body mass index BMI has increased worldwide. The prevalence of obesity BMI 30 kg m2 in the USA is now over 30 among adults 1 . This leads to a substantial increase in obesity-related diseases and costs. Obesity is the result of an imbalance between energy intake and energy expenditure and these processes are normally controlled by genetic .