tailieunhanh - Báo cáo y học: "Lung surfactant in subacute pulmonary disease"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:"Lung surfactant in subacute pulmonary disease. | Available online http content 3 1 19 Review Lung surfactant in subacute pulmonary disease Gehan Devendra1 and Roger G Spragg2 1 University of California San Diego California USA. 2San Diego Veterans Affairs Medical Center San Diego California USA. Correspondence Roger G Spragg - rspragg@ Received 1 November 2001 Revisions requested 9 January 2002 Revisions received 18 February 2002 Accepted 20 February 2002 Published 4 April 2002 Respir Res 2002 3 1 9 2002 BioMed Central Ltd Print ISSN 1465-9921 Online ISSN 1465-993X Abstract Pulmonary surfactant is a surface active material composed of both lipids and proteins that is produced by alveolar type II pneumocytes. Abnormalities of surfactant in the immature lung or in the acutely inflamed mature lung are well described. However in a variety of subacute diseases of the mature lung abnormalities of lung surfactant may also be of importance. These diseases include chronic obstructive pulmonary disease asthma cystic fibrosis interstitial lung disease pneumonia and alveolar proteinosis. Understanding of the mechanisms that disturb the lung surfactant system may lead to novel rational therapies for these diseases. Keywords asthma interstitial pulmonary fibrosis pneumonia pulmonary alveolar proteinosis pulmonary surfactant Introduction Lung surfactant is a highly surface active substance that is synthesized by alveolar epithelial type II cells and composed of approximately 80 phospholipids 10 proteins and 10 neutral lipids. The predominate phospholipids are phosphatidylcholine PC and phosphatidylglycerol phosphatidylinositol and sphingomyelin contribute to the total concentration. Two of the surfactant-associated proteins SP-A and SP-D have important host defense properties 1 while the remaining two SP-B and SP-C are intensely hydrophobic and interact with surfactant phospholipids to optimize surface tension lowering function. After synthesis surfactant is stored in lamellar bodies and .

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