tailieunhanh - Báo cáo y học: " Skeletal muscle dysfunction in chronic obstructive pulmonary disease"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: Skeletal muscle dysfunction in chronic obstructive pulmonary disease. | Available online http content 2 4 216 Review Skeletal muscle dysfunction in chronic obstructive pulmonary disease M Jeffery Mador and Erkan Bozkanat Division of Pulmonary Critical Care Sleep Medicine State University of New York at Buffalo Veterans Administration Medical Center Buffalo New York USA GATA Camlica Hospital of Chest Diseases Istanbul Turkey Correspondence M Jeffery Mador MD Associate Professor of Medicine Division of Pulmonary Critical Care Sleep Medicine Section 111S State University of New York at Buffalo Veterans Administration Medical Center 3495 Bailey Avenue Buffalo NY 14215 USA. Tel 1 716 862 8629 fax 1 716 862 8632 e-mail Mador@ Received 6 February 2001 Revisions requested 13 March 2001 Revisions received 5 April 2001 Accepted 5 April 2001 Published 2 May 2001 Respir Res 2001 2 216-224 2001 BioMed Central Ltd Print ISSN 1465-9921 Online ISSN 1465-993X Abstract It has become increasingly recognized that skeletal muscle dysfunction is common in patients with chronic obstructive pulmonary disease COPD . Muscle strength and endurance are decreased whereas muscle fatigability is increased. There is a reduced proportion of type I fibers and an increase in type II fibers. Muscle atrophy occurs with a reduction in fiber cross-sectional area. Oxidative enzyme activity is decreased and measurement of muscle bioenergetics during exercise reveals a reduced aerobic capacity. Deconditioning is probably very important mechanistically. Other mechanisms that may be of varying importance in individual patients include chronic hypercapnia and or hypoxia nutritional depletion steroid usage and oxidative stress. Potential therapies include exercise training oxygen supplementation nutritional repletion and administration of anabolic hormones. Keywords exercise lung diseases muscle nutrition disorder obstructive rehabilitation skeletal Introduction COPD is a chronic debilitating disease with disabling symptoms. Our ability to