tailieunhanh - Báo cáo y học: "Genomic approaches to research in pulmonary hypertension"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "Genomic approaches to research in pulmonary hypertension" | Available online http content 2 4 210 Review Genomic approaches to research in pulmonary hypertension Mark W Geraci Bifeng Gao Yasushi Hoshikawa Michael E Yeager Rubin M Tuder and Norbert F Voelkel Division of Pulmonary Sciences and Critical Care Medicine University of Colorado Health Sciences Center Denver Colorado USA Department of Pathology Johns Hopkins University School of Medicine USA Correspondence Mark W Geraci MD Division of Pulmonary Sciences and Critical Care Medicine University of Colorado Health Sciences Center Campus Box C-272 4200 East Ninth Avenue Denver CO 80262 USA. Tel 1 303 315 7047 fax 1 303 315 5632 e-mail Received 16 February 2001 Revisions requested 13 March 2001 Revisions received 22 March 2001 Accepted 3 April 2001 Published 1 May 2001 Respir Res 2001 2 210-215 2001 BioMed Central Ltd Print ISSN 1465-9921 Online ISSN 1465-993X Abstract Genomics or the study of genes and their function is a burgeoning field with many new technologies. In the present review we explore the application of genomic approaches to the study of pulmonary hypertension PH . Candidate genes important to the pathobiology of the disease have been investigated. Rodent models enable the manipulation of selected genes either by transgenesis or targeted disruption. Mutational analysis of genes in the transforming growth factor-p family have proven pivotal in both familial and sporadic forms of primary PH. Finally microarray gene expression analysis is a robust molecular tool to aid in delineating the pathobiology of this disease. Keywords genetic mutation knockout mouse microarray pulmonary hypertension transgenic mouse Introduction Pulmonary hypertension PH refers to a spectrum of diseases where the pulmonary artery pressure is elevated. A new classification of PH has recently been proposed 1 . No cause can be elucidated in primary or sporadic idiopathic pulmonary hypertension PPH . Secondary forms of PH can occur in .

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