tailieunhanh - Báo cáo y học: "The lung as a route for systemic delivery of therapeutic proteins and peptides"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:"The lung as a route for systemic delivery of therapeutic proteins and peptides" | Available online http content 2 4 198 Review The lung as a route for systemic delivery of therapeutic proteins and peptides Remigius Uchenna Agu Michael Ikechukwu Ugwoke Michoel Armand Renaat Kinget and Norbert Verbeke Laboratorium voor Farmacotechnologie en Biofarmacie KU Leuven Leuven Belgium Octoplus Pharmaceutical Development Leiden The Netherlands Correspondence Norbert Verbeke Laboratorium voor Farmacotechnologie en Biofarmacie KU Leuven Campus Gasthuisberg O N Herestraat 49 B-3000 Leuven Belgium. Tel 32 1634 5824 fax 32 1634 5996 e-mail Received 25 January 2001 Revisions requested 13 February 2001 Revisions received 9 March 2001 Accepted 13 March 2001 Published 12 April 2001 Respir Res 2001 2 198-209 2001 BioMed Central Ltd Print ISSN 1465-9921 Online ISSN 1465-993X Abstract The large surface area good vascularization immense capacity for solute exchange and ultra-thinness of the alveolar epithelium are unique features of the lung that can facilitate systemic delivery via pulmonary administration of peptides and proteins. Physical and biochemical barriers lack of optimal dosage forms and delivery devices limit the systemic delivery of biotherapeutic agents by inhalation. Current efforts to overcome these difficulties in order to deliver metabolic hormones insulin calcitonin thyroid-stimulating hormone TSH follicle-stimulating hormone FSH and growth hormones systemically to induce systemic responses immunoglobulins cyclosporin A CsA recombinant-methionyl human granulocyte colony-stimulating factor r-huG-CSF pancreatic islet autoantigen and to modulate other biological processes via the lung are reviewed. Safety aspects of pulmonary peptide and protein administration are also discussed. Keywords lung peptides proteins pulmonary absorption systemic delivery Introduction The techniques of recombinant DNA technology have been well refined during the past 20 years such that it is now possible to produce