tailieunhanh - Báo cáo khoa hoc:" Effect of venlafaxine on bone loss associated with ligature-induced periodontitis in Wistar rats"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Effect of venlafaxine on bone loss associated with ligature-induced periodontitis in Wistar rats | Carvalho et al. Journal of Negative Results in BioMedicine 2010 9 3 http content 9 1 3 RESEARCH JOURNAL OF NEGATIVE RESULTS IN BIOMEDICINE Open Access Effect of venlafaxine on bone loss associated with ligature-induced periodontitis in Wistar rats Rosimary S Carvalho 1 2 Carolina M de Souza1 Julliana CS Neves1 Sergio A Holanda-Pinto2 Lívia MS Pinto2 Gerly AC Brito3 and Geanne M de Andrade1 Abstract Background The present study investigated the effects of venlafaxine an antidepressant drug with immunoregulatory properties on the inflammatory response and bone loss associated with experimental periodontal disease EPD . Materials and Methods Wistar rats were subjected to a ligature placement around the second upper left molar. The treated groups received orally venlafaxine 10 or 50 mg kg one hour before the experimental periodontal disease induction and daily for 10 days. Vehicle-treated experimental periodontal disease and a sham-operated SO controls were included. Bone loss was analyzed morphometrically and histopathological analysis was based on cell influx alveolar bone and cementum integrity. Lipid peroxidation quantification and immunohistochemistry to TNF-a and iNOS were performed. Results Experimental periodontal disease rats showed an intense bone loss compared to SO ones SO EPD mm p and evidenced increased cellular infiltration and immunoreactivity for TNF-a and iNOS. Venlafaxine treatment while at low dose 10 mg kg afforded no significant protection against bone loss mm a high dose 50 mg kg caused significantly enhanced bone loss mm p . Venlafaxine effectively decreased the lipid peroxidation but showed no significant change in TNF-a or iNOS immunoreactivity. Conclusion The increased bone loss associated with high dose venlafaxine may possibly be a result of synaptic inhibition of serotonin uptake. Introduction Although depression and periodontitis are common conditions in older adults past .

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