tailieunhanh - Báo cáo y học: "Recent advances in our understanding of human host responses to tuberculosis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:"Recent advances in our understanding of human host responses to tuberculosis | Available online http content 2 3 157 Review Recent advances in our understanding of human host responses to tuberculosis Neil W Schluger Associate Professor of Medicine and Public Health Columbia University College of Physicians and Surgeons New York USA Correspondence Neil W Schluger MD Division of Pulmonary Allergy and Critical Care Medicine Columbia Presbyterian Medical Center PH-8 Center 630 West 168th Street New York NY 10032 USA. Tel 1 2I2 305 9817 fax 1 212 342 5272 e-mail ns311@ Received 15 February 2001 Revisions requested 1 March 2001 Revisions received 2 March 2001 Accepted 2 March 2001 Published 29 March 2001 Respir Res 2001 2 157-163 2001 BioMed Central Ltd Print ISSN 1465-9921 Online ISSN 1465-993X Abstract Tuberculosis remains one of the world s greatest public health challenges 2 billion persons have latent infection 8 million people develop active tuberculosis annually and 2-3 million die. Recently significant advances in our understanding of the human immune response against tuberculosis have occurred. The present review focuses on recent work in macrophage and T-cell biology that sheds light on the human immune response to tuberculosis. The role of key cytokines such as interferon-Y is discussed as is the role of CD4 and CD8 T cells in immune regulation in tuberculosis particularly with regard to implications for vaccine development and evaluation. Keywords CD4 cell CD8 cell immunity interferon tuberculosis Introduction Tuberculosis remains one of the most important infectious diseases in the world 1 . It is estimated that 2 billion persons on the planet harbor latent tuberculosis infection. Eight to 12 million new cases of active tuberculosis occur each year and at any given time there are approximately 16 million persons with active tuberculosis in the world. These cases result in 2-3 million deaths annually making tuberculosis the single leading cause of death of any infectious disease. These figures are .