tailieunhanh - Báo cáo y học: " Eotaxin and the attraction of eosinophils to the asthmatic lung"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" Eotaxin and the attraction of eosinophils to the asthmatic lung | Available online http content 2 3 150 Review Eotaxin and the attraction of eosinophils to the asthmatic lung Dolores M Conroy and Timothy J Williams Leukocyte Biology Section Biomedical Sciences Division Imperial College School of Medicine London UK Correspondence Dolores M Conroy Leukocyte Biology Section Biomedical Sciences Division Sir Alexander Fleming Building Imperial College School of Medicine London SW7 2AZ UK. Tel 44 20 7594 3118 fax 44 20 7594 3119 e-mail Received 6 February 2001 Accepted 1 March 2001 Published 29 March 2001 Respir Res 2001 2 150-156 2001 BioMed Central Ltd Print ISSN 1465-9921 Online ISSN 1465-993X Abstract Eosinophilic leukocytes accumulate in high numbers in the lungs of asthmatic patients and are believed to be important in the pathogenisis of asthma. A potent eosinophil chemoattractant is produced in the asthmatic lung. This small protein the chemokine eotaxin is synthesized by a number of different cell types and is stimulated by interleukin-4 and interleukin-13 which are produced by T-helper Th 2 lymphocytes. Low molecular weight compounds have been developed that can block the eotaxin receptor C-C chemokine receptor CCR 3 and prevent stimulation by eotaxin. This provides the potential for orally available drugs that can prevent eosinophil recruitment into the lung and the associated damage and dysfunction. Keywords allergy asthma chemokines eosinophils eotaxin Introduction The eosinophil was originally identified as a unique type of white cell in the blood which is characterized by its bilobed nucleus and its cytoplasmic granules that stain pink with eosin 1 . An early observation was that this cell accumulates in the asthmatic lung 2 but its significance was not recognized. Subsequently eosinophils have become identified through our defence system against helminth parasites. Parasitic worms characteristically induce an immune response that is polarized toward Th2 lymphocytes. These cells

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