tailieunhanh - Báo cáo y học: "Immunologists getting nervous: neuropeptides, dendritic cells and T cell activation"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:Immunologists getting nervous: neuropeptides, dendritic cells and T cell activation | Available online http content 2 3 133 Commentary Immunologists getting nervous neuropeptides dendritic cells and T cell activation Bart N Lambrecht Erasmus Medical Center Rotterdam Rotterdam The Netherlands o 3 I Correspondence Bart N Lambrecht MD PhD Department of Pulmonary and Critical Care Medicine Erasmus University Rotterdam Room Ee2263 Dr Molewaterplein 50 3015 GE Rotterdam The Netherlands. Tel 31 10 4087703 fax 31 10 4089453 e-mail lambrecht@ Received 20 February 2001 Revisions requested 13 March 2001 Revisions received 21 March 2001 Accepted 4 April 2001 Published 19 April 2001 Respir Res 2001 2 133-138 2001 BioMed Central Ltd Print ISSN 1465-9921 Online ISSN 1465-993X Abstract It is increasingly recognised that the immune and nervous systems are closely integrated to optimise defence systems within the lung. In this commentary the contribution of various neuropeptides such as substance P calcitonin gene-related peptide vasoactive intestinal peptide and somatostatin to the regulation of T cell activation is discussed. These neuropeptides are released not only from nerve endings but also from inflammatory immune cells such as monocytes dendritic cells eosinophils and mast cells. On release they can exert both direct stimulatory and inhibitory effects on T cell activation and also indirect effects through their influence on the recruitment and activation of professional antigen-presenting dendritic cells. Neuropeptides should therefore be included in the conceptual framework of the immune regulation of T cell function by dendritic cells. Keywords calcitonin gene-related peptide dendritic cells substance P T cells vasoactive intestinal peptide Introduction Homeostasis within the body is regulated by three interwoven systems the endocrine nervous and immune systems 1 . It is increasingly clear that exchange of information between these systems is facilitated by the endocrine and or paracrine release of hormones neuromediators