tailieunhanh - Báo cáo y học: " A new direction in the pathogenesis of idiopathic pulmonary fibrosis?"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " A new direction in the pathogenesis of idiopathic pulmonary fibrosis. | Available online http content 3 1 1 Commentary A new direction in the pathogenesis of idiopathic pulmonary fibrosis Jack Gauldie Martin Kolb and Patricia J Sime Department of Pathology and Molecular Medicine Centre for Gene Therapeutics McMaster University Hamilton Ontario Canada Department of Medicine Pulmonary and Critical Care Unit University of Rochester School of Medicine Rochester New York USA Correspondence Jack Gauldie Department of Pathology and Molecular Medicine Centre for Gene Therapeutics McMaster University 1200 Main St W Hamilton Ontario Canada L8N 3Z5. Tel 1 905 521 2100 ext 76332 fax 1 905 577 0198 e-mail gauldie@ Received 30 July 2001 Accepted 8 August 2001 Published 26 September 2001 Respir Res 2002 3 1 2002 BioMed Central Ltd Print ISSN 1465-9921 Online ISSN 1465-993X Abstract A recent review article suggested that idiopathic pulmonary fibrosis IPF is a disease that is associated more with abnormal wound healing than with inflammation. Data derived from transgenic and gene transfer rodent models suggest that lung inflammation may be a necessary but insufficient component of IPF and that at some point in the natural history of the disease IPF becomes no longer dependent on the inflammatory response for propagation. Altered microenvironment and involvement of epithelial cell mesenchymal cell interaction are the most likely contributors to the pathogenesis of this chronic progressive disorder. Keywords fibrosis inflammation myofibroblast tissue repair transforming growth factor TGF -p Introduction An excellent recent review of IPF by Selman et al. 1 outlines current concepts regarding pathogenesis and suggests a new hypothesis for the aetiology of this progressive and usually fatal disease. IPF has recently been classified in diagnostic pathology terms as usual interstitial pneumonia UIP in order to differentiate it from other forms of pneumonitis that are associated with different pathogeneses and a more .