tailieunhanh - Báo cáo y học: " Implications of post-pneumonectomy compensatory lung growth in pulmonary physiology and disease"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" Implications of post-pneumonectomy compensatory lung growth in pulmonary physiology and disease. | Available online http content 2 6 340 Review Implications of post-pneumonectomy compensatory lung growth in pulmonary physiology and disease Lynn M Brown Stephen R Rannels and D Eugene Rannels Department of Cellular Molecular Physiology The Pennsylvania State University College of Medicine Hershey Pennsylvania USA Correspondence D Eugene Rannels PhD Department of Cellular Molecular Physiology C4600D The Pennsylvania State University College of Medicine H166 500 University Drive Hershey PA 17033 USA. Tel 1 717 531 8556 fax 1 717 531 7667 e-mail grannels@ Received 30 April 2001 Revisions requested 20 June 2001 Revisions received 6 July 2001 Accepted 25 July 2001 Published 21 August 2001 Respir Res 2001 2 340-347 2001 BioMed Central Ltd Print ISSN 1465-9921 Online ISSN 1465-993X Abstract In a number of species partial pneumonectomy initiates hormonally regulated compensatory growth of the remaining lung lobes that restores normal mass structure and function. Compensation is qualitatively similar across species but differs with gender age and hormonal status. Although the biology of response is best characterized in rats dogs have proven valuable in defining post-operative physiological adaptations. Most recently mice were recognized to offer unique opportunities to explore the genetic basis of the response as well as to evaluate associated detrimental effects of pathophysiological significance in animals exposed to carcinogens. The pneumonectomy model thus offers powerful insight concerning adaptive organ growth. Keywords biomechanical signaling cellular differentiation lung growth metastatic tumors pulmonary carcinogenesis Introduction Partial pneumonectomy PNX the surgical removal of a lung lobe or lobes substantially diminishes diffusion capacity by reducing the total number of alveoli and the associated vasculature available for gas exchange. The immediate challenge to a pneumonectomized animal is to maintain adequate gas exchange .