tailieunhanh - Báo cáo y học: "Th2 cytokines and asthma Interleukin-9 as a therapeutic target for asthma"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "Th2 cytokines and asthma Interleukin-9 as a therapeutic target for asthma". | Available online http content 2 2 080 Review Th2 cytokines and asthma Interleukin-9 as a therapeutic target for asthma Yuhong Zhou Michael McLane and Roy C Levitt Magainin Pharmaceuticals Inc Plymouth Meeting Pennsylvania USA Correspondence Roy C Levitt Magainin Pharmaceuticals Inc 5110 Campus Drive Plymouth Meeting PA 19462 USA. Tel 1 610 941 5248 fax 1 610 941 5399 e-mail rlevitt@ Received 13 December 2000 Accepted 8 January 2001 Published 15 February 2001 Respir Res 2001 2 80-84 2001 BioMed Central Ltd Print ISSN 1465-9921 Online ISSN 1465-993X Abstract Asthma is a complex heritable inflammatory disorder of the airways in which the development of clinical disease depends on environmental exposure. It has been well established that T helper type 2 TH2 lymphocytes and their cytokines have an important role in allergic asthma. Interleukin IL -9 a member of the Th2 cytokine family has recently been implicated as an essential factor in determining mucosal immunity and susceptibility to atopic asthma. In this review we examine the critical experiments and observations that support this hypothesis. We also discuss these results in comparison with the experiments supporting the involvement of other TH2 cytokines such as IL-4 IL-5 and IL-13. Keywords asthma genetics interleukin-9 target transgenic Introduction Asthma is a complex heritable inflammatory disorder of the airways associated with airway obstruction as well as a variety of clinical signs 1 2 . Airway hyperresponsiveness AHR a risk factor and a cardinal feature of asthma is characterized as an exaggerated airway response to an irritant stimulus resulting in airway obstruction. Asthma is commonly associated with chronic elevation of serum IgE another risk factor for the disorder which is closely associated with allergy. Allergic asthma atopic asthma is the most common accounting for 90 of cases under 30 years of age 3 . In addition asthmatics frequently suffer from mucus .