tailieunhanh - Báo cáo y học: "Combined treatment with dexamethasone and raloxifene totally abrogates osteoporosis and joint destruction in experimental postmenopausal arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Combined treatment with dexamethasone and raloxifene totally abrogates osteoporosis and joint destruction in experimental postmenopausal arthritis. | Islander et al. Arthritis Research Therapy 2011 13 R96 http content 13 3 R96 RESEARCH ARTICLE Open Access Combined treatment with dexamethasone and raloxifene totally abrogates osteoporosis and joint destruction in experimental postmenopausal arthritis Ulrika Islander f Caroline Jochems1 Alexandra Stubelius Annica Andersson Marie K Lagerquist Claes Ohlsson and Hans Carlsten Abstract Introduction Postmenopausal patients with rheumatoid arthritis RA are often treated with corticosteroids. Loss of estrogen the inflammatory disease and exposure to corticosteroids all contribute to the development of osteoporosis. Therefore our aim was to investigate if addition of the selective estrogen receptor modulator raloxifene or estradiol could prevent loss of bone mineral density in ovariectomized and dexamethasone treated mice with collagen-induced arthritis CIA . Methods Female DBA 1-mice were ovariectomized or sham-operated and CIA was induced. Treatment with dexamethasone Dex 125 qg d estradiol E2 1 qg d or raloxifene Ral 120 qg day alone or the combination of Dex E2 or Dex Ral was started after disease onset and continued until termination of the experiments. Arthritic paws were collected for histology and one of the femoral bones was used for measurement of bone mineral density. Results Dex-treatment alone protected against arthritis and joint destruction but had no effect on osteoporosis in CIA. However additional treatment with either Ral or E2 resulted in completely preserved bone mineral density. Conclusions Addition of raloxifene or estradiol to dexamethasone-treatment in experimental postmenopausal polyarthritis prevents generalized bone loss. Keywords Raloxifene Estradiol Dexamethasone collagen-induced arthritis bone mineral density Introduction Rheumatoid arthritis RA is a progressive systemic autoimmune disease with a prevalence of about to 1 1 and it is characterized by symmetrical polyarthritis. Several findings indicate the .