tailieunhanh - Báo cáo y học: " Matrix metalloproteinases in lung biology"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Matrix metalloproteinases in lung biolog. | Available online http content 2 1 010 Review Matrix metalloproteinases in lung biology William C Parks and Steven D Shapiro Department of Pediatrics Department of Medicine and Department of Cell Biology and Physiology Washington University School of Medicine St Louis Missouri USA Correspondence William C Parks PhD Department of Pediatrics Box 8208 Washington University School of Medicine 660 South Euclid Avenue St Louis MO 63110 USA. Tel 1 314 286 2862 fax 1 314 286 2894 e-mail parks_w@ Received 16 November 2000 Accepted 7 December 2000 Published 29 December 2000 Respir Res 2001 2 10-19 2001 BioMed Central Ltd Print ISSN 1465-9921 Online ISSN 1465-993X Abstract Despite much information on their catalytic properties and gene regulation we actually know very little of what matrix metalloproteinases MMPs do in tissues. The catalytic activity of these enzymes has been implicated to function in normal lung biology by participating in branching morphogenesis homeostasis and repair among other events. Overexpression of MMPs however has also been blamed for much of the tissue destruction associated with lung inflammation and disease. Beyond their role in the turnover and degradation of extracellular matrix proteins MMPs also process activate and deactivate a variety of soluble factors and seldom is it readily apparent by presence alone if a specific proteinase in an inflammatory setting is contributing to a reparative or disease process. An important goal of MMP research will be to identify the actual substrates upon which specific enzymes act. This information in turn will lead to a clearer understanding of how these extracellular proteinases function in lung development repair and disease. Keywords cystic fibrosis emphysema epithelium innate defense wound repair Introduction MMPs comprise a large family of extracellular enzymes that share common structural features particularly those regions involved in the regulation of proteolytic