tailieunhanh - Báo cáo y học: "Effects of intravenous furosemide on mucociliary transport and rheological properties of patients under mechanical ventilation"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Effects of intravenous furosemide on mucociliary transport and rheological properties of patients under mechanical ventilation. | Available online http content 6 1 081 Research article Effects of intravenous furosemide on mucociliary transport and rheological properties of patients under mechanical ventilation Cláudia Seiko Kondo 1- Mariângela Macchionne Naomi Kondo Nakagawa 1- Carlos Roberto Ribeiro de Carvalho Malcolm King Paulo Hilário Nascimento Saldiva Geraldo Lorenzi-Filho Universidade de São Paulo São Paulo Brazil Universidade Federal de São Paulo and Escola Paulista de Medicina São Paulo Brazil Pulmonary Research Group Edmonton Alberta Canada Correspondence Geraldo Lorenzi-Filho Received 14 February 2001 Revisions requested 31 August 2001 Revisions received 19 September 2001 Accepted 23 October 2001 Published 19 November 2001 Critical Care 2002 6 81-87 2002 Kondo et al. licensee BioMed Central Ltd Print ISSN 1364-8535 Online ISSN 1466-609X Abstract The use of intravenous IV furosemide is common practice in patients under mechanical ventilation MV but its effects on respiratory mucus are largely unknown. Furosemide can affect respiratory mucus either directly through inhibition of the NaK Cl 2 co-transporter on the basolateral surface of airway epithelium or indirectly through increased diuresis and dehydration. We investigated the physical properties and transportability of respiratory mucus obtained from 26 patients under MV distributed in two groups furosemide n 12 and control n 14 . Mucus collection was done at 0 1 2 3 and 4 hours. The rheological properties of mucus were studied with a microrheometer and in vitro mucociliary transport MCT frog palate contact angle CA and cough clearance CC simulated cough machine were measured. After the administration of furosemide MCT decreased by 17 19 24 11 18 16 and 18 13 at 1 2 3 and 4 hours respectively P compared with control. In contrast no significant changes were observed in the control group. The remaining parameters did not change significantly in either group. Our results support the .