tailieunhanh - Báo cáo y học: "Role of γδ T cells in protecting normal airway function"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:Role of γδ T cells in protecting normal airway function. | http content 1 3 151 Review Role of y6 T cells in protecting normal airway function Willi K Born Michael Lahn Katsuyuki Takeda Arihiko Kanehiro Rebecca L O Brien and Erwin W Gelfand National Jewish Medical and Research Center Denver Colorado USA Received 18 August 2000 Revisions requested 25 August 2000 Revisions received 25 September 2000 Accepted 27 September 2000 Published 7 November 2000 Respir Res 2000 1 151-158 Current Science Ltd Print ISSN 1465-9921 Online ISSN 1465-993X Abstract Since their discovery 15 years ago the role of yS T cells has remained somewhat elusive. Responses of yS T cells have been found in numerous infectious and non-infectious diseases. New evidence points to yS T cells functioning in the airways to maintain normal airway responsiveness or tone. In the lung distinct subsets of yS T cell subsets seem to have specific roles one subset promoting allergic inflammation the other serving a protective role. Keywords airway hyper-responsiveness asthma yS T cells lymphocytes Introduction 76 T cells In the mid-1980s it became clear that lymphocytes expressing two novel rearranging genes Y and s represent a distinct subset 1-4 now called yS T cells. Current evidence indicates that yS T cells have co-evolved during the past 500 million years or so with ap T cells and B lymphocytes 5 and that they are evolutionarily preserved in a wide range of species probably including all higher vertebrates 6 . In rodents and primates yS T cells form relatively small subsets of lymphocytes which raises questions about their importance. Indeed there is only some evidence that in adults yS T cells are required for that most quintessential of immune functions host protection against infections although they are probably protective early in life 7 . However responses of yS T cells have been found in numerous diseases both infectious and non-infectious and data are accumulating to suggest that a primary role of these cells is immune regulation