tailieunhanh - Báo cáo y học: " Mimicking microbial ‘education’ of the immune system: a strategy to revert the epidemic trend of atopy and allergic asthma?"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:Mimicking microbial ‘education’ of the immune system: a strategy to revert the epidemic trend of atopy and allergic asthma. | http content 1 3 129 Commentary Mimicking microbial education of the immune system a strategy to revert the epidemic trend of atopy and allergic asthma Paolo Maria Matricardi and Sergio Bonini DASRS Pomezia Rome and institute of Experimental Medicine CNR Rome Italy o 3 I Received 30 June 2000 Revisions requested 30 August 2000 Revisions received 8 September 2000 Accepted 8 September 2000 Published 25 October 2000 Respir Res 2000 1 129-132 Current Science Ltd Print ISSN 1465-9921 Online ISSN 1465-993X Abstract Deficient microbial stimulation of the immune system caused by hygiene may underly the atopy and allergic asthma epidemic we are currently experiencing. Consistent with this hygiene hypothesis research on immunotherapy of allergic diseases also centres on bacteria-derived molecules eg DNA immunostimulatory sequences as adjuvants for allergen-specific type 1 immune responses. If we understood how certain microbes physiologically educate our immune system to interact safely with environmental nonmicrobial antigens we might be able to learn to mimic their beneficial actions. Programmed immunoeducation would consist of safe administration by the correct route dose and timing of those microbial stimuli that are necessary to train the developing mucosal immune system and to maintain an appropriate homeostatic equilibrium between its components. Overall this would result in a prevention of atopy that is not limited to certain specific allergens. Although such a strategy is far beyond our present potential it may in principle revert the epidemic trend of atopy and allergic asthma without jeopardizing the fight against infectious diseases. Keywords allergy asthma DNA immunostimulatory sequences epidemiology lactobacilli lipopolysaccharide mycobacteria prevention therapy Introduction Allergic asthma is on the increase in Western countries as are efforts to identify the reasons for this increase 1 . This trend is part of a generalized increase in

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