tailieunhanh - Báo cáo y học: "Transcriptional regulation of lung development: emergence of specificity"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:Transcriptional regulation of lung development: emergence of specificity. | http content 1 2 109 Review Transcriptional regulation of lung development emergence of specificity Parviz Minoo University of Southern California School of Medicine Los Angeles California USA Received 4 August 2000 Revisions requested 14 August 2000 Revisions received 24 August 2000 Accepted 24 August 2000 Published 1 September 2000 Respir Res 2000 1 109-115 Current Science Ltd Print ISSN 1465-9921 Online ISSN 1465-993X Abstract The lung is the product of a set of complex developmental interactions between two distinct tissues the endodermally derived epithelium and the mesoderm. Each tissue contributes to lung development by fine-tuning the spatial and temporal pattern of gene expression for a distinct array of signaling molecules transcriptional molecules and molecules related to the extracellular matrix. Morphoregulatory transcriptional factors such as have the crucial role of connecting the cell-cell crosstalk to the activation or repression of gene expression through which processes such as cellular proliferation migration differentiation and apoptosis can be controlled. Although none of the factors participating in lung development are exclusively lung-specific their unique combinations and interactions constitute the basis for emergence of lung structural and functional specificities. An understanding of the individual molecules and their unique interactions in the context of lung development is necessary for the construction of a morphogenetic map for this vital organ as well as for the development of rational and innovative approaches to congenital and induced lung disease. Keywords alveolar type I cell alveolar type II cell Bmp4 epithelial-mesenchymal interactions extracellular matrix protein Fgf-10 growth factors Hnf3 lung morphogenesis morphogens Shh transcription factors Introduction Temporal and spatial control of gene expression by transcriptional factors is a hallmark of development. The lung is no exception .