tailieunhanh - Báo cáo y học: " Surfactant protein-D and pulmonary host defense"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:Surfactant protein-D and pulmonary host defense. | http content 1 2 093 Review Surfactant protein-D and pulmonary host defense Erika C Crouch Washington University School of Medicine St Louis Missouri USA Received 26 July 2000 Accepted 9 August 2000 Published 25 August 2000 Respir Res 2000 1 93-108 Current Science Ltd Print ISSN 1465-9921 Online ISSN 1465-993X Abstract Surfactant protein-D SP-D participates in the innate response to inhaled microorganisms and organic antigens and contributes to immune and inflammatory regulation within the lung. SP-D is synthesized and secreted by alveolar and bronchiolar epithelial cells but is also expressed by epithelial cells lining various exocrine ducts and the mucosa of the gastrointestinal and genitourinary tracts. SP-D a collagenous calcium-dependent lectin or collecting binds to surface glycoconjugates expressed by a wide variety of microorganisms and to oligosaccharides associated with the surface of various complex organic antigens. SP-D also specifically interacts with glycoconjugates and other molecules expressed on the surface of macrophages neutrophils and lymphocytes. In addition SP-D binds to specific surfactant-associated lipids and can influence the organization of lipid mixtures containing phosphatidylinositol in vitro. Consistent with these diverse in vitro activities is the observation that SP-D-deficient transgenic mice show abnormal accumulations of surfactant lipids and respond abnormally to challenge with respiratory viruses and bacterial lipopolysaccharides. The phenotype of macrophages isolated from the lungs of SP-D-deficient mice is altered and there is circumstantial evidence that abnormal oxidant metabolism and or increased metalloproteinase expression contributes to the development of emphysema. The expression of SP-D is increased in response to many forms of lung injury and deficient accumulation of appropriately oligomerized SP-D might contribute to the pathogenesis of a variety of human lung diseases. Keywords eolleetins

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