tailieunhanh - Báo cáo y học: " The role of secretory leukocyte proteinase inhibitor and elafin (elastase-specific inhibitor/skin-derived antileukoprotease) as alarm antiproteinases in inflammatory lung disease"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: The role of secretory leukocyte proteinase inhibitor and elafin (elastase-specific inhibitor/skin-derived antileukoprotease) as alarm antiproteinases in inflammatory lung disease. | http content 1 2 087 Review The role of secretory leukocyte proteinase inhibitor and elafin elastase-specific inhibitor skin-derived antileukoprotease as alarm antiproteinases in inflammatory lung disease Jean-Michel Sallenave Edinburgh Medical School Edinburgh Scotland UK Received 18 July 2000 Revisions requested 3 August 2000 Revisions received 7 August 2000 Accepted 7 August 2000 Published 23 August 2000 Respir Res 2000 1 87-92 Current Science Ltd Print ISSN 1465-9921 Online ISSN 1465-993X Abstract Secretory leukocyte proteinase inhibitor and elafin are two low-molecular-mass elastase inhibitors that are mainly synthesized locally at mucosal sites. It is thought that their physicochemical properties allow them to efficiently inhibit target enzymes such as neutrophil elastase released into the interstitium. Historically in the lung these inhibitors were first purified from secretions of patients with chronic obstructive pulmonary disease and cystic fibrosis. This suggested that they might be important in controlling excessive neutrophil elastase release in these pathologies. They are upregulated by alarm signals such as bacterial lipopolysaccharides and cytokines such as interleukin-1 and tumor necrosis factor and have been shown to be active against Gram-positive and Gram-negative bacteria so that they have joined the growing list of antimicrobial defensin-like peptides produced by the lung. Their site of synthesis and presumed functions make them very attractive candidates as potential therapeutic agents under conditions in which the excessive release of elastase by neutrophils might be detrimental. Because of its natural tropism for the lung the use of adenovirus-mediated gene transfer is extremely promising in such applications. Keywords adenovirus ela n elastase-specific inhibitor skin-derived antileukoprotease elastase inflammation secretory leukocyte proteinase inhibitor Introduction Cytokines form one of the major classes of .

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