tailieunhanh - Báo cáo y học: " Nitric oxide: a pro-inflammatory mediator in lung disease?"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: Nitric oxide: a pro-inflammatory mediator in lung disease. | http content 1 2 067 Commentary Nitric oxide a pro-inflammatory mediator in lung disease Albert van der Vliet Jason P Eiserich and Carroll E Cross University of California Davis California USA and University of Alabama at Birmingham Birmingham Alabama USA o 3 I Received 29 June 2000 Revisions requested 26 July 2000 Revisions received 31 July 2000 Accepted 31 July 2000 Published 15 August 2000 Respir Res 2000 1 67-72 Current Science Ltd Print ISSN 1465-9921 Online ISSN 1465-993X Abstract Inflammatory diseases of the respiratory tract are commonly associated with elevated production of nitric oxide NO and increased indices of NO -dependent oxidative stress. Although NO is known to have anti-microbial anti-inflammatory and anti-oxidant properties various lines of evidence support the contribution of NO to lung injury in several disease models. On the basis of biochemical evidence it is often presumed that such NO -dependent oxidations are due to the formation of the oxidant peroxynitrite although alternative mechanisms involving the phagocyte-derived heme proteins myeloperoxidase and eosinophil peroxidase might be operative during conditions of inflammation. Because of the overwhelming literature on NO generation and activities in the respiratory tract it would be beyond the scope of this commentary to review this area comprehensively. Instead it focuses on recent evidence and concepts of the presumed contribution of NO to inflammatory diseases of the lung. Keywords inflammation neutrophil nitric oxide nitrotyrosine peroxidases Introduction Since its discovery as a biological messenger molecule more than 10 years ago the gaseous molecule nitric oxide NO is now well recognized for its involvement in diverse biological processes including vasodilation bronchodilation neurotransmission tumor surveillance antimicrobial defense and regulation of inflammatory-immune processes 1-3 . In the respiratory tract NO is generated enzymically by three .