tailieunhanh - Báo cáo y học: " Viruses, dendritic cells and the lung"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:Viruses, dendritic cells and the lung. | Available online http content 2 4 245 Review Viruses dendritic cells and the lung R Stokes Peebles Jr and Barney S Graham1 Department of Medicine Vanderbilt University School of Medicine Nashville Tennessee USA Vaccine Research Center National Institutes of Health Bethesda Maryland USA Correspondence Barney S Graham MD PhD Vaccine Research Center Building 40 Room 2502 40 Covent Drive National Institutes of Health Bethesda MA 20892-3005 USA. Tel 1 301 594 8468 fax 1 301 480 2771 e-mail bgraham@ Received 14 March 2001 Revisions requested 30 April 2001 Revisions received 8 May 2001 Accepted 18 May 2001 Published 27 June 2001 Respir Res 2001 2 245-249 2001 BioMed Central Ltd Print ISSN 1465-9921 Online ISSN 1465-993X Abstract The interaction between viruses and dendritic cells DCs is varied and complex. DCs are key elements in the development of a host response to pathogens such as viruses but viruses have developed survival tactics to either evade or diminish the immune system that functions to kill and eliminate these micro-organisms. In the present review we summarize current concepts regarding the function of DCs in the immune system our understanding of how viruses alter DC function to attenuate both the virusspecific and global immune response and how we may be able to exploit DC function to prevent or treat viral infections. Keywords dendritic cell inflammation lung virus Introduction Many viruses utilize the respiratory tract as an entry point into the host. They may target specialized cells of the respiratory tract for initial replication leading to disease that primarily manifests as illnesses of the lung and upper airways. Alternatively they may infect mobile elements that are resident in the respiratory tract or produce viremia that can carry the virus to a secondary target organ. The outcome of these encounters is determined by the early events that occur in the lung at the interface of the innate and adaptive immune .