tailieunhanh - Báo cáo khoa hoc:" Dipolar cortico-muscular electrical stimulation: a novel method that enhances motor function in both - normal and spinal cord injured mice"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Dipolar cortico-muscular electrical stimulation: a novel method that enhances motor function in both - normal and spinal cord injured mice | Ahmed Journal of NeuroEngineering and Rehabilitation 2010 7 46 http content 7 1 46 l dl JOURNAL OF NEUROENGINEERING NCR AND REHABILITATION RESEARCH Open Access Dipolar cortico-muscular electrical stimulation a novel method that enhances motor function in both - normal and spinal cord injured mice Zaghloul Ahmed Abstract Background Electrical stimulation of the central and peripheral nervous systems is a common tool that is used to improve functional recovery after neuronal injury. Methods Here we described a new configuration of electrical stimulation as it was tested in anesthetized control and spinal cord injury SCI mice. Constant voltage output was delivered through two electrodes. While the negative voltage output ranging from to V was delivered to the muscle via transverse wire electrodes diameter 500 pm located at opposite ends of the muscle the positive output ranging from to V was delivered to the primary motor cortex M1 electrode tip 100 pm . The configuration was named dipolar cortico-muscular stimulation dCMS and consisted of 100 pulses 1 ms pulse duration 1 Hz frequency . Results In SCI animals after dCMS cortically-elicited muscle contraction improved markedly at the contralateral 456 and ipsilateral 457 gastrocnemius muscles. The improvement persisted for the duration of the experiment 60 min . The enhancement of cortically-elicited muscle contraction was accompanied by the reduction of M1 maximal threshold and the potentiation of spinal motoneuronal evoked responses at the contralateral 313 and ipsilateral 292 sides of the spinal cord. Moreover spontaneous activity recorded from single spinal motoneurons was substantially increased contralaterally 121 and ipsilaterally 54 . Interestingly spinal motoneuronal responses and muscle twitches evoked by the test stimulation of non-treated M1 received no dCMS were significantly enhanced as well. Similar results obtained from normal animals albeit the changes were .