tailieunhanh - Báo cáo y học: " Cardiovascular events in early RA are a result of inflammatory burden and traditional risk factors: a five year prospective study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Cardiovascular events in early RA are a result of inflammatory burden and traditional risk factors: a five year prospective study. | Innala et al. Arthritis Research Therapy 2011 13 R131 http content 13 4 R131 RESEARCH ARTICLE Open Access Cardiovascular events in early RA are a result of inflammatory burden and traditional risk factors a five year prospective study 12 1 3 4 1 Lena Innala Bozena Moller Lotta Ljung Staffan Magnusson Torgny Smedby Anna Sodergren Marie-Louise Ohman5 Solbritt Rantapaa-Dahlqvist1 and Solveig Wallberg-Jonsson1 Abstract Introduction Co-morbidity and mortality due to cardiovascular disease CVD are increased in patients with rheumatoid arthritis RA . Most published studies in this field are retrospective or cross sectional. We investigated the presence of traditional and disease related risk factors for CVD at the onset of RA and during the first five years following diagnosis. We also evaluated their potential for predicting a new cardiovascular event CVE during the five-year follow-up period and the modulatory effect of pharmacological treatment. Methods All patients from the four northern-most counties of Sweden with early RA are since December 1995 consecutively recruited at diagnosis T0 into a large survey on the progress of the disease. Information regarding cardiovascular co-morbidity and related predictors was collected from clinical records and supplemented with questionnaires. By April 2008 700 patients had been included of whom 442 patients had reached the five-year follow-up T5 . Results Among the 442 patients who reached T5 during the follow-up period treatment for hypertension increased from to P diagnosis of diabetes mellitus DM from to P whilst smoking decreased from to P and the BMI from to P respectively. By T5 48 patients had suffered a new CVE of which 12 were fatal. A total of 23 patients died during the follow-up period. Age at disease onset male sex a previous CVE DM treatment for hypertension triglyceride level cumulative disease activity area under the curve AUC .