tailieunhanh - Báo cáo y học: " Pathophysiological classification of chronic rhinosinusitis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: Pathophysiological classification of chronic rhinosinusitis. | Respiratory Research BioMed Central Research Pathophysiological classification of chronic rhinosinusitis James N Baraniuk and Hilda Maibach Open Access Address Georgetown University Proteomics Laboratory Division of Rheumatology Immunology and Allergy Room B105 Lower Level Kober-Cogan Building Georgetown University 3800 Reservoir Road NW Washington DC 20007-2197 USA Email James N Baraniuk - baraniuj@ Hilda Maibach - hildamaibach@ Corresponding author Published 19 December 2005 Received 16 June 2005 Respiratory Research 2005 6 149 doi 1465-9921-6-149 Accepted 19 December 2005 This article is available from http content 6 1 149 2005 Baraniuk and Maibach licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Recent consensus statements demonstrate the breadth of the chronic rhinosinusitis CRS differential diagnosis. However the classification and mechanisms of different CRS phenotypes remains problematic. Method Statistical patterns of subjective and objective findings were assessed by retrospective chart review. Results CRS patients were readily divided into those with 50 99 and without 49 99 polyposis. Aspirin sensitivity was limited to 17 50 polyp subjects. They had peripheral blood eosinophilia and small airways obstruction. Allergy skin tests were positive in 71 of the remaining polyp subjects. IgE was 10 IU ml in 8 38 polyp and 20 45 nonpolyp subjects p Fisher s Exact test . CT scans of the CRS without polyp group showed sinus mucosal thickening probable glandular hypertrophy in 28 49 and nasal osteomeatal disease in 21 49. Immunoglobulin isotype deficiencies were more prevalent in nonpolyp than polyp subjects p . Conclusion CRS subjects .

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