tailieunhanh - Báo cáo y học: " Cigarette smoke-induced pulmonary emphysema in scid-mice. Is the acquired immune system required?"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Cigarette smoke-induced pulmonary emphysema in scid-mice. Is the acquired immune system required?. | Respiratory Research BioMed Central Research Open Access Cigarette smoke-induced pulmonary emphysema in scid-mice. Is the acquired immune system required An I D hulst Tania Maes Ken R Bracke Ingel K Demedts Kurt G Tournoy Guy F Joos and Guy G Brusselle Address Department of Respiratory Diseases Ghent University Hospital Ghent Belgium Email An I D hulst - Tania Maes - Ken R Bracke - Ingel K Demedts - Kurt GTournoy - Guy F Joos - Guy G Brusselle - Corresponding author Published 16 December 2005 Received 07 July 2005 Accepted 16 December 2005 Respiratory Research 2005 6 147 doi 1465-9921-6-147 This article is available from http content 6 1 147 2005 D hulst et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Chronic obstructive pulmonary disease is associated with a chronic inflammatory response of the host to chronic exposure to inhaled toxic gases and particles. Although inflammatory cells of both the innate and adaptive immune system infiltrate the lungs in pulmonary emphysema and form lymphoid follicles around the small airways the exact role of the acquired immune system in the pathogenesis of emphysema is not known. Methods In this study wild type Balb c mice and immunodeficient scid mice - which lack functional B- and T-cells - were exposed to mainstream cigarette smoke CS for 5 weeks or 6 months. Results Subacute CS-exposure for 5 weeks significantly increased innate inflammatory cells neutrophils macrophages and dendritic cells in the bronchoalveolar lavage BAL fluid of wild type mice and scid mice which correlated with