tailieunhanh - Báo cáo khoa hoc:" Comparison between the HCV IRES domain IV RNA structure and the Iron Responsive Element"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Comparison between the HCV IRES domain IV RNA structure and the Iron Responsive Element | Journal of Negative Results in BioMedicine BioMed Central Research Comparison between the HCV IRES domain IV RNA structure and the Iron Responsive Element Ebenezer Tumban1 2 Jenna M Painter2 and William B Lott 1 2 3 Address 1Molecular Biology Program New Mexico State University Las Cruces NM 88003-8001 USA 2Department of Chemistry and Biochemistry New Mexico State University Las Cruces NM 88003-8001 USA and Institute for Health and Biomedical Innovation School of Life Sciences Queensland University of Technology Brisbane QLD 4001 Australia Email Ebenezer Tumban - etumban@ Jenna M Painter - jmp_scholarships2004@ William B Lott - Corresponding author Open Access Published 18 February 2009 Received 13 November 2007 Journal of Negative Results in BioMedicine 2009 8 4 doi l 477-5751-8-4 Accepted 18 February 2009 This article is available from http content 8 1 4 2009 Tumban et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Serum ferritin and hepatic iron concentrations are frequently elevated in patients who are chronically infected with the hepatitis C virus HCV and hepatic iron concentration has been used to predict response to interferon therapy but these correlations are not well understood. The HCV genome contains an RNA structure resembling an iron responsive element IRE in its internal ribosome entry site IRES structural domain IV dIV . An IRE is a stem loop structure used to control the expression of eukaryotic proteins involved in iron homeostasis by either inhibiting ribosomal binding or protecting the mRNA from nuclease degradation. The HCV structure located within the binding site of the 40S ribosomal subunit might function as an .