tailieunhanh - Báo cáo y học: " Invasive versus noninvasive measurement of allergic and cholinergic airway responsiveness in mice"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" Invasive versus noninvasive measurement of allergic and cholinergic airway responsiveness in mice. | Respiratory Research BioMed Central Research Open Access Invasive versus noninvasive measurement of allergic and cholinergic airway responsiveness in mice Thomas Glaab1 2 Michaela Ziegert1 Ralf Baelder1 Regina Korolewitz1 Armin Braun1 Jens M Hohlfeld1 2 Wayne Mitzner3 Norbert Krug1 and Heinz G Hoymann 1 Address 1Fraunhofer Institute of Toxicology and Experimental Medicine ITEM Nikolai-Fuchs 30625 Hannover Germany 2Hannover Medical School Department of Respiratory Medicine Carl-Neuberg 30625 Hannover Germany and 3Division of Physiology Bloomberg School of Public Health Johns Hopkins University Baltimore Maryland 21205 USA Email Thomas Glaab - thomasglaab@ Michaela Ziegert - michaela@ Ralf Baelder - Regina Korolewitz - korolewitz@ Armin Braun - braun@ Jens M Hohlfeld - hohlfeld@ Wayne Mitzner - wmitzner@ Norbert Krug - krug@ Heinz G Hoymann - hoymann@ Corresponding author Published 25 November 2005 Received 18 January 2005 Accepted 25 November 2005 Respiratory Research 2005 6 139 doi 86 1465-9921-6-139 This article is available from http content 6 1 1 39 2005 Glaab et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background This study seeks to compare the ability of repeatable invasive and noninvasive lung function methods to assess allergen-specific and cholinergic airway responsiveness AR in intact spontaneously breathing BALB c mice. Methods Using noninvasive head-out body plethysmography and the decrease in tidal midexpiratory flow EF50 we determined early AR EAR to inhaled Aspergillus fumigatus antigens in conscious mice. .