tailieunhanh - Báo cáo y học: "Decreases in serum levels of S100A8/9 (calprotectin) correlate with improvements in total swollen joint count in patients with recent-onset rheumatoid arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Decreases in serum levels of S100A8/9 (calprotectin) correlate with improvements in total swollen joint count in patients with recent-onset rheumatoid arthritis. | Andrés Cerezo et al. Arthritis Research Therapy 2011 13 R122 http content 13 4 R122 RESEARCH ARTICLE Open Access Decreases in serum levels of S100A8 9 calprotectin correlate with improvements in total swollen joint count in patients with recent-onset rheumatoid arthritis 1 12 111 Lucie Andrés Cerezo Herman Mann Ondrej Pecha Lenka Plestilová Karel Pavelka Jiri Vencovský and Ladislav Senolt1 Abstract Introduction The aim of this study was to examine the serum levels of S100 proteins and to evaluate their role in patients with recent-onset rheumatoid arthritis RA . Methods Serum levels of S100A8 9 and S100A12 were analysed in 43 patients with recent-onset RA both before and three months after the initiation of conventional treatment as well as in 32 healthy individuals. Disease activity was assessed based on serum levels of C-reactive protein CRP the Disease Activity Score for 28 joints DAS28 and the total number of swollen joints count for 66 joints SJC . Results The levels of serum S100A8 9 and S100A12 were significantly higher in patients with recent-onset RA compared to the levels in healthy individuals P and normalised after three months of treatment. Using age- and sex-adjusted analysis S100A8 9 levels were correlated with CRP r P DAS28 r P and SJC r P while S100A12 was less significantly correlated with these parameters. Higher levels of S100A8 9 at baseline predicted improvement in the levels of CRP and SJC over time. Moreover decreases in serum S100A8 9 were associated with decreased serum levels of CRP r P and improvements in SJC r P . In multiple linear regression analyses decreases in S100A8 9 but not CRP were significant predictors for improvements in SJC P . Conclusions This study is the first to show normalisation of elevated S100 proteins in patients with recent-onset RA after the initiation of conventional treatment. Therefore S100A8 9 might potentially be a