tailieunhanh - Báo cáo khoa hoc:" No evidence of enhanced oxidant production in blood obtained from patients with obstructive sleep apnea"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: No evidence of enhanced oxidant production in blood obtained from patients with obstructive sleep apnea | BioMed Central Journal of Negative Results in BioMedicine Research No evidence of enhanced oxidant production in blood obtained from patients with obstructive sleep apnea Izabela Grabska-Kobylecka1 Andrzej Kobylecki1 Piotr Bialasiewicz1 Maciej Krol1 Golsa Ehteshamirad1 Marek Kasielski2 and Dariusz Nowak 1 Address 1Sleep and Respiratory Disorders Center of the Chair of Experimental and Clinical Physiology Medical University of Lodz 92-215 Lodz Mazowiecka St. 6 8 Poland and 2Bases of Clinical Medicine Teaching Center Medical University of Lodz 90-153 Lodz Kopcinskiego St. 20 Poland Email Izabela Grabska-Kobylecka - izagra@ AndrzejKobylecki - izagra@ Piotr Bialasiewicz - pbialasiewicz@ MaciejKrol - Golsa Ehteshamirad - golsa_er@ Marek Kasielski - kasielsm@ Dariusz Nowak - dnowak@ Corresponding author Published 25 November 2008 Received II May 2008 - n J I--7I-I -7 1 Accepted 25 November 2008 Journal of Negative Results in BioMedicine 2008 7 10 doi 1477-5751-7-10 This article is available from http content 7 1 10 2008 Grabska-Kobylecka et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract_ Background Obstructive sleep apnea syndrome OSAS is a recognized risk factor for cardiovascular morbidity and mortality perhaps due to causative exacerbations of systemic oxidative stress. Putative oxidative stress related to numerous episodes of intermittent hypoxia may be an oxidants chief driving force in OSAS patients. Methods We assessed the resting and n-formyl-methionyl-leucyl-phenylalanine fMLP - induced whole blood .