tailieunhanh - Báo cáo y học: " Downregulation of peroxisome proliferator-activated receptors (PPARs) in nasal polyposis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: Downregulation of peroxisome proliferator-activated receptors (PPARs) in nasal polyposis. | Respiratory Research BioMed Central Research Open Access Downregulation of peroxisome proliferator-activated receptors PPARs in nasal polyposis Lars-Olaf Cardell Magnus Hagge Rolf Uddman and Mikael Adner Address Laboratory of Clinical and Experimental Allergy Research Department of Otorhinolaryngology Lund University Malmo University Hospital Malmo Sweden Email Lars-Olaf Cardell - Magnus Hagge - RolfUddman - Mikael Adner - Corresponding author Published 07 November 2005 Received 03 April 2005 Accepted 07 November 2005 Respiratory Research 2005 6 132 doi 1465-9921-6-1 32 This article is available from http content 6 1 132 2005 Cardell et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Peroxisome proliferator-activated receptor PPAR a p and Y are nuclear receptors activated by fatty acid metabolites. An anti-inflammatory role for these receptors in airway inflammation has been suggested. Methods Nasal biopsies were obtained from 10 healthy volunteers and 10 patients with symptomatic allergic rhinitis. Nasal polyps were obtained from 22 patients before and after 4 weeks of local steroid treatment fluticasone . Real-time RT-PCR was used for mRNA quantification and immunohistochemistry for protein localization and quantification. Results mRNA expression of PPARa PPARpỗ PPARy was found in all specimens. No differences in the expression of PPARs were obtained in nasal biopsies from patients with allergic rhinitis and healthy volunteers. Nasal polyps exhibited lower levels of PPARa and PPARy than normal nasal mucosa and these levels were for PPARy further reduced following steroid .

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