tailieunhanh - Báo cáo y học: " Isolation of human β-defensin-4 in lung tissue and its increase in lower respiratory tract infection"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: Isolation of human β-defensin-4 in lung tissue and its increase in lower respiratory tract infection. | Respiratory Research BioMed Central Research Open Access Isolation of human p-defensin-4 in lung tissue and its increase in lower respiratory tract infection Shigehisa Yanagi 1 Jun-ichi Ashitani1 Hiroshi Ishimoto2 Yukari Date1 Hiroshi Mukae2 Naoyoshi Chino3 and Masamitsu Nakazato1 Address Third Department of Internal Medicine Miyazaki University School of Medicine Miyazaki 889-1692 Japan 2Second Department of Internal Medicine Nagasaki University School of Medicine Nagasaki 852-8501 Japan and 3Peptide Institute Inc. Osaka 562-8686 Japan Email Shigehisa Yanagi - shigeyana2002@ Jun-ichi Ashitani - jashi2@ Hiroshi Ishimoto - hiro08193103@ Yukari Date - dateyuka@ Hiroshi Mukae - hmukae@ Naoyoshi Chino - chino@ Masamitsu Nakazato - nakazato@ Corresponding author Published 04 November 2005 Received 21 July 2005 Accepted 04 November 2005 Respiratory Research 2005 6 130 doi 1465-9921-6-130 This article is available from http content 6 1 1 30 2005 Yanagi et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Human P-defensin-4 hBD-4 a new member of the P-defensin family was discovered by an analysis of the genomic sequence. The objective of this study was to clarify hBD-4 expression in human lung tissue along with the inducible expression in response to infectious stimuli localization and antimicrobial activities of hBD-4 peptides. We also investigated the participation of hBD-4 in chronic lower respiratory tract infections LRTI by measuring the concentrations of hBD-4 peptides in human bronchial epithelial lining fluid ELF . Methods The antimicrobial activity of .