tailieunhanh - Báo cáo y học: " The crucial role of particle surface reactivity in respirable quartz-induced reactive oxygen/nitrogen species "

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: The crucial role of particle surface reactivity in respirable quartz-induced reactive oxygen/nitrogen species . | BioMed Central Respiratory Research Research Open Access The crucial role of particle surface reactivity in respirable quartz-induced reactive oxygen nitrogen species formation and APE Ref-1 induction in rat lung Catrin Albrecht - 1 Ad M Knaapen11 2 Andrea Becker1 Doris Hohr1 Petra Haberzettl1 Frederik J van Schooten2 Paul JA Borm1 and Roel PF Schins1 Address 1Institut fur Umweltmedizinische Forschung IUF at the Heinrich-Heine-University Dusseldorf Germany and 2Nutrition and Toxicology Research Institute Maastricht NUTRIM Department of Health Risk Analysis and Toxicology University of Maastricht The Netherlands Email Catrin Albrecht - Ad M Knaapen - Andrea Becker - Andrea-Becker@ Doris Hohr - Petra Haberzettl - Frederik J van Schooten - Paul JA Borm - Roel PF Schins - Corresponding author fEqual contributors Published 02 November 2005 Received 21 July 2005 Accepted 02 November 2005 Respiratory Research 2005 6 129 doi 1465-9921-6-129 This article is available from http content 6 1 129 2005 Albrecht et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Persistent inflammation and associated excessive oxidative stress have been crucially implicated in quartz-induced pulmonary diseases including fibrosis and cancer. We have investigated the significance of the particle surface reactivity of respirable quartz dust in relation to the in vivo generation of reactive oxygen and nitrogen species ROS RNS and the associated induction of oxidative stress responses in the lung. .