tailieunhanh - Báo cáo y học: " Wound trauma mediated inflammatory signaling attenuates a tissue regenerative response in MRL/MpJ mice"

Tham khảo luận văn - đề án 'báo cáo y học: " wound trauma mediated inflammatory signaling attenuates a tissue regenerative response in mrl/mpj mice"', luận văn - báo cáo phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả | Zins et al. Journal of Inflammation 2010 7 25 http content 7 1 25 JOURNAL OF INFLAMMATION RESEARCH Open Access Wound trauma mediated inflammatory signaling attenuates a tissue regenerative response in MRL MpJ mice Stephen R Zins 1 Mihret F Amare1 Khairul Anam1 Eric A Elster1 2 and Thomas A Davis 1 Abstract Background Severe trauma can induce pathophysiological responses that have marked inflammatory components. The development of systemic inflammation following severe thermal injury has been implicated in immune dysfunction delayed wound healing multi-system organ failure and increased mortality. Methods In this study we examined the impact of thermal injury-induced systemic inflammation on the healing response of a secondary wound in the MRL MpJ mouse model which was anatomically remote from the primary site of trauma a wound that typically undergoes scarless healing in this specific strain. Ear-hole wounds in MRL MpJ mice have previously displayed accelerated healing and tissue regeneration in the absence of a secondary insult. Results Severe thermal injury in addition to distal ear-hole wounds induced marked local and systemic inflammatory responses in the lungs and significantly augmented the expression of inflammatory mediators in the ear tissue. By day 14 61 of the ear-hole wounds from thermally injured mice demonstrated extensive inflammation with marked inflammatory cell infiltration extensive ulceration and various level of necrosis to the point where a large percentage 38 had to be euthanized early during the study due to extensive necrosis inflammation and ear deformation. By day 35 ear-hole wounds in mice not subjected to thermal injury were completely closed while the ear-hole wounds in thermally injured mice exhibited less inflammation and necrosis and only closed partially 62 . Thermal injury resulted in marked increases in serum levels of IL-6 TNFa KC CXCL1 and MIP-2a CXCL2 . Interestingly attenuated early ear wound .