tailieunhanh - Báo cáo sinh học: "Bactericidal activity of oxacillin and glycopeptides against Staphylococcus aureus in patients with endocarditis: Looking for a relationship between tolerance and outcome"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí y học Molecular Biology cung cấp cho các bạn kiến thức về ngành sinh học đề tài: Bactericidal activity of oxacillin and glycopeptides against Staphylococcus aureus in patients with endocarditis: Looking for a relationship between tolerance and outcome. | Pasticci et al. Annals of Clinical Microbiology and Antimicrobials 2011 10 26 http content 10 1 26 ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS RESEARCH Open Access Bactericidal activity of oxacillin and glycopeptides against Staphylococcus aureus in patients with endocarditis Looking for a relationship between tolerance and outcome 1 1 1 2 2 3 Maria Bruna Pasticci Amedeo Moretti Giuliano Stagni Veronica Ravasio Laura Soavi Annibale Raglio 3 1 1111 Francesca Vailati Angela Cardaccia Antonella Santucci Rita Papili Alessio Sgrelli Carlo Pallotto and Franco Baldelli1 Abstract Background There is no clear relationship between in vitro bactericidal activity tests and clinical outcome. We studied bactericidal activity of oxacillin vancomycin and teicoplanin against Staphylococcus aureus isolates in patients with endocarditis and then we sought to determine if there was a relationship between in vitro bactericidal activity and clinical outcome. Methods Minimal bacteriostatic and minimal bactericidal concentrations were determined for Staphylococcus aureus strains isolated from patients with endocarditis following standardized methods. Medical records were reviewed retrospectively to collect data on antimicrobial susceptibility at admission antimicrobial therapy need for surgery embolic events and outcome. Results and Discussion Sixty-two Staphylococcus aureus strains were studied in 62 patients with endocarditis. Overall definite 21 methicillin resistant and cured. Surgery was performed in and embolic events were documented in . Tolerance to oxacillin and teicoplanin was more common than vancomycin tolerance among methicillin susceptible Staphylococcus aureus. Among methicillin resistant Staphylococcus aureus teicoplanin was shown to have a higher rate of tolerance than vancomycin. No statistically significant differences on clinical outcome between oxacillin tolerant and oxacillin non tolerant Staphylococcus aureus .

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