tailieunhanh - Báo cáo sinh học: "An image processing approach to computing distances between RNA secondary structures dot plots"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí y học Molecular Biology cung cấp cho các bạn kiến thức về ngành sinh học đề tài: An image processing approach to computing distances between RNA secondary structures dot plots. | Algorithms for Molecular Biology BioMed Central Research An image processing approach to computing distances between RNA secondary structures dot plots Tor Ivry1 Shahar Michal1 Assaf Avihoo1 Guillermo Sapiro2 and Danny Barash 1 Address Department of Computer Science Ben-Gurion University Beersheba Israel and 2Department of Electrical and Computer Engineering University of Minnesota Minneapolis USA Email Tor Ivry - ivryt@ Shahar Michal - mshaha@ Assaf Avihoo - avihoo@ Guillermo Sapiro - guille@ Danny Barash - dbarash@ Corresponding author Open Access Published 9 February 2009 Received 23 March 2007 Algorithms for Molecular Biology 2009 4 4 doi l748-7l 88-4-4 Accepted 9 February 2009 This article is available from http content 4 1 4 2009 Ivry et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Computing the distance between two RNA secondary structures can contribute in understanding the functional relationship between them. When used repeatedly such a procedure may lead to finding a query RNA structure of interest in a database of structures. Several methods are available for computing distances between RNAs represented as strings or graphs but none utilize the RNA representation with dot plots. Since dot plots are essentially digital images there is a clear motivation to devise an algorithm for computing the distance between dot plots based on image processing methods. Results We have developed a new metric dubbed DoPloCompare which compares two RNA structures. The method is based on comparing dot plot diagrams that represent the secondary structures. When analyzing two diagrams and motivated by image processing the distance .

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