tailieunhanh - Báo cáo sinh học: "Finding the region of pseudo-periodic tandem repeats in biological sequences"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí y học Molecular Biology cung cấp cho các bạn kiến thức về ngành sinh học đề tài: Finding the region of pseudo-periodic tandem repeats in biological sequences. | Algorithms for Molecular Biology BioMed Central Research Open Access Finding the region of pseudo-periodic tandem repeats in biological sequences Xiaowen Liu and Lusheng Wang Address Department of Computer Science City University of Hong Kong Kowloon Hong Kong Email Xiaowen Liu - liuxw@ Lusheng Wang - lwang@ Corresponding authors Published 28 February 2006 Algorithms for Molecular Biology2006 1 2 doi 1748-7188-1-2 This article is available from http content 1 1 2 Received 23 February 2006 Accepted 28 February 2006 2006Liu and Wang licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Summary The genomes of many species are dominated by short sequences repeated consecutively. It is estimated that over 10 of the human genome consists of tandemly repeated sequences. Finding repeated regions in long sequences is important in sequence analysis. We develop a software LocRepeat that finds regions of pseudo-periodic repeats in a long sequence. We use the definition of Li et al. 1 for the pseudo-periodic partition of a region and extend the algorithm that can select the repeated region from a given long sequence and give the pseudo-periodic partition of the region. Availability LocRepeat is available at http lwang software LocRepeat Background Finding pseudo-periodic repeats or tandem repeats is an important task in biological sequence analysis 1-3 . The genomes of many species are dominated by short sequences repeated consecutively. It is estimated that over 10 of the human genome consists of tandemly repeated sequences. About 10-25 of all known proteins have some form of repeated structure ranging from simple homopolymers to multiple duplications of entire

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